Kick things off by heating your oven to 350°F. Give a standard loaf pan a generous coating of non-stick spray so nothing gets left behind.

In your largest mixing bowl, introduce the ground turkey to its spice cabinet friends: the salt, pepper, smoked paprika, thyme, cumin, oregano, and Worcestershire sauce. Use a fork or clean hands to marry these flavors together.

Once the spices are integrated, pour in the milk, drop in the eggs, and sprinkle the panko across the surface. Fold everything together gently—overworking turkey can make it tough, so treat it with a light touch until just combined.

Transfer your mixture into the prepared pan. Smooth the top with a spatula or your palm to ensure even cooking. Slide it into the center rack of the oven and let it roast for 35 minutes.

While the meatloaf begins its transformation, grab a small bowl. Vigorously whisk the ketchup, honey, vinegar, and mustard until you have a glossy, ruby-red glaze.

Carefully pull the pan out and drape that sweet-and-tangy glaze over the top. Return it to the heat for a final 10-minute stint to let the glaze caramelize and set.

Allow the loaf to sit for 5 minutes before slicing. This ensures the juices stay put. Garnish with a handful of fresh green onions and serve.